	   SnapGene      sTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTGGTTTAGTGAACCGTCAGATCCGCTAGCGCCACCatggacgggtccggggagcagcccagaggcggggggcccaccagctctgagcagatcatgaagacaggggcccttttgcttcagggtttcatccaggatcgagcagggcgaatggggggggaggcacccgagctggccctggacccggtgcctcaggatgcgtccaccaagaagctgagcgagtgtctcaagcgcatcggggacgaactggacagtaacatggagctgcagaggatgattgccgccgtggacacagactccccccgagaggtctttttccgagtggcagctgacatgttttctgacggcaacttcaactggggccgggttgtcgcccttttctactttgccagcaaactggtgctcaaggccctgtgcaccaaggtgccggaactgatcagaaccatcatgggctggacattggacttcctccgggagcggctgttgggctggatccaagaccagggtggttgggacggcctcctctcctactttgggacgcccacgtggcagaccgtgaccatctttgtggcgggagtgctcaccgccgaactcaccatctggaagaagatgggcggcggcagcggcggcagcCTCGAGGCCACCatgaagatggacaaaaagactatagtttggtttagaagagacctaaggattgaggataatcctgcattagcagcagctgctcacgaaggatctgtttttcctgtcttcatttggtgtcctgaagaagaaggacagttttatcctggaagagcttcaagatggtggatgaaacaatcacttgctcacttatctcaatccttgaaggctcttggatctgacctcactttaatcaaaacccacaacacgatttcagcgatcttggattgtatccgcgttaccggtgctacaaaagtcgtctttaaccacctctatgatcctgtttcgttagttcgggaccataccgtaaaggagaagctggtggaacgtgggatctctgtgcaaagctacaatggagatctattgtatgaaccgtgggagatatactgcgaaaagggcaaaccttttacgagtttcaattcttactggaagaaatgcttagatatgtcgattgaatccgttatgcttcctcctccttggcggttgatgccaataactgcagcggctgaagcgatttgggcgtgttcgattgaagaactagggctggagaatgaggccgagaaaccgagcaatgcgttgttaactagagcttggtctccaggatggagcaatgctgataagttactaaatgagttcatcgagaagcagttgatagattatgcaaagaacagcaagaaagttgttgggaattctacttcactactttctccgtatctccatttcggggaaataagcgtcagacacgttttccagtgtgcccggatgaaacaaattatatgggcaagagataagaacagtgaaggagaagaaagtgcagatctttttcttaggggaatcggtttaagagagtattctcggtatatatgtttcaacttcccgtttactcacgagcaatcgttgttgagtcatcttcggtttttcccttgggatgctgatgttgataagttcaaggcctggagacaaggcaggaccggttatccgttggtggatgccggaatgagagagctttgggctaccggatggatgcataacagaataagagtgattgtttcaagctttgctgtgaagtttcttctccttccatggaaatggggaatgaagtatttctgggatacacttttggatgctgatttggaatgtgacatccttggctggcagtatatctctgggagtatccccgatggccacgagcttgatcgcttggacaatcccgcgttacaaggcgccaaatatgacccagaaggtgagtacataaggcaatggcttcccgagcttgcgagattgccaactgaatggatccatcatccatgggacgctcctttaaccgtactcaaagcttctggtgtggaactcggaacaaactatgcgaaacccattgtagacatcgacacagctcgtgagctactagctaaagctatttcaagaacccgtgaagcacagatcatgatcggagcagcaGCCCGGGATCCACCGGTCGCCACCATGGTGAGCAAGGGCGAGGAGGATAACATGGCCATCATCAAGGAGTTCATGCGCTTCAAGGTGCACATGGAGGGCTCCGTGAACGGCCACGAGTTCGAGATCGAGGGCGAGGGCGAGGGCCGCCCCTACGAGGGCACCCAGACCGCCAAGCTGAAGGTGACCAAGGGTGGCCCCCTGCCCTTCGCCTGGGACATCCTGTCCCCTCAGTTCATGTACGGCTCCAAGGCCTACGTGAAGCACCCCGCCGACATCCCCGACTACTTGAAGCTGTCCTTCCCCGAGGGCTTCAAGTGGGAGCGCGTGATGAACTTCGAGGACGGCGGCGTGGTGACCGTGACCCAGGACTCCTCCCTGCAGGACGGCGAGTTCATCTACAAGGTGAAGCTGCGCGGCACCAACTTCCCCTCCGACGGCCCCGTAATGCAGAAGAAGACCATGGGCTGGGAGGCCTCCTCCGAGCGGATGTACCCCGAGGACGGCGCCCTGAAGGGCGAGATCAAGCAGAGGCTGAAGCTGAAGGACGGCGGCCACTACGACGCTGAGGTCAAGACCACCTACAAGGCCAAGAAGCCCGTGCAGCTGCCCGGCGCCTACAACGTCAACATCAAGTTGGACATCACCTCCCACAACGAGGACTACACCATCGTGGAACAGTACGAACGCGCCGAGGGCCGCCACTCCACCGGCGGCATGGACGAGCTGTACAAGTAGCGGCCGCGACTCTAGATCATAATCAGCCATACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAACCTCCCACACCTCCCCCTGAACCTGAAACATAAAATGAATGCAATTGTTGTTGTTAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTAAGGCGTAAATTGTAAGCGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCACCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGGCGCGTCAGGTGGCACTTTTCGGGGAAATGTGCGCGGAACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAGACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTCCTGAGGCGGAAAGAACCAGCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCGGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAGATCGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAAGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGAGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCTAGGGGGAGGCTAACTGAAACACGGAAGGAGACAATACCGGAAGGAACCCGCGCTATGACGGCAATAAAAAGACAGAATAAAACGCACGGTGTTGGGTCGTTTGTTCATAAACGCGGGGTTCGGTCCCAGGGCTGGCACTCTGTCGATACCCCACCGAGACCCCATTGGGGCCAATACGCCCGCGTTTCTTCCTTTTCCCCACCCCACCCCCCAAGTTCGGGTGAAGGCCCAGGGCTCGCAGCCAACGTCGGGGCGGCAGGCCCTGCCATAGCCTCAGGTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGCCTTTTGCTGGCCTTTTGCTCACATGTTCTTTCCTGCGTTATCCCCTGATTCTGTGGATAACCGTATTACCGCCATGCAT  :ç   &   )      +   $   %   (   $       
         /      +   (   %         )   3   !      "            $               "            
                  "            
      &            +            1      "      "         +   %   #      %      %                     %   "   %      +   -      !   $             $                        *         !                              #                                                %         &   5      (      (                                                                                 $                               A   %            !                  *                           "               )   ,                                 2   #         %   ,                     %            $   %   %                           #   #            #            (         #   %   !                '      )        &   fxyzœËÌÍÎÏ ™¯	b£<¶^!^às§úôõöš›ëìí)   7¡Ãß!gÐ!2Io&Tˆ°y	0	k	ù	’
aÊ`Š¤Ã==BVÃáU�œ  ¶ `­Ÿ*JßcÙd´_^tÛ¿÷w»+ ‡{�Ãšô–gáøæÍ±
í
)¿[ŽB!5×ß%·R_"û¯�¨èûëî$ 3 º Ä"hÑ7p>Uý8ý—l	…
·
Ï
ê
Ëa‹ÒöhîV‚�ò% ßŒH‡‰±½	 	I	
%
-õ¥¿Ä>J¨¸Èß'>ôŠ¶'+|�û( �¢¹õBæí[Š¼'4Ôz¶ÕÙ1	=	ê	“
º
r'-Hdð	Z�ÏâI«ÙY$ ¡ 8à\æ"+Rù 3JÀ9£Ž	ú	bàû
¬	ZC½ÉWÄÄ`  · kìÁÙ+(XÏ³¶	
¨
á
AKìj/Ú"eÛ‡µXÜPò
 K Å 4el§ s”8® .Ô½!m¨™ýBàT¿`«uõÀø¼  %ag,œ
Ädòû_zçx/ ˆuÄl—š£ºâ¡	²
äçƒ�°ïR`"6­¶Øà&µ¸S¢EUmºñôüªß]ï Õ FyÐÔvŒV�¦hçŸ]	Ã	*,U¸æ2÷?€õ`<†ÿs+ [ õƒÓùÎY	É	î
~À\Ÿë3®ùmu�©ýH”¥¸#>°Õü°Ë‚é&�ì( R |žà›Ê7±’z	Ã
ú
N†Ad³ÖCn®<ËÑÚ\
‘¬©â\ +% #sÒ@e¯ëµ
¸
ë
'½Þb}�Â@—h³ÉÏô÷+kóX� cÝ?Vþ
[ìþ(˜ÂÄÙ	’Ù¹!iƒŠœµ'>Wƒ 4 » ÅrqvR*bëm	¹	Ð
 äü¬Hï~) 3iŠ¾Û
8L&9TÆ€	Ñ	R
†
«
Ìn^ŒšÓáàäHëRŽ07…‘Ðó3 •��ºÚ036I€ˆ×ï]ú 	%	³	s
>�­"OR‹£©ÜÀÅ©ûCì8?Võè(ßSR! _b‹~²Ø	3
Æ²%¦»ÈÎ?¢¹à(…Ó‹e§Ÿ@Yžü Ç¡ Š¾å!	J	æ	ÒÐÉã~÷·K" @&àê Mòuó
&
k
ö
×.7ÀöH€°K½?ç1,jð"} nöC“½U\Á5Õ{�·ÖÚ>	w	Ôs9(E™˜ñ
pÐà ŽîX•Cfî‡2	»
Û�ß‘`7­ÏÚ)Z £Fç­½�ÜëjïD	Û	”;Iž$Œ’)-×Q$ I�ºå‹¶ð(A†	ë	{
�
”
”{.e³[ÓãJV¤¬· x „ ­  	º]#‰4Kû	á>€­¼[ ð,REvÅ9Ì ˜,S}úÁ:¿šP	�	@
F
cœ
�#‰ÊGa ¢ 9™áYÉ¥üt²{D¦XÅË _ j /ç%Z`ß�¤­	2DïõUÊÕÎÒÈf¾ jnžk–" ¸ ‹Pt,TjY$R´
LÈê+@´0ÆÝ%fˆª¸ó›¨W l>^øí	N	·	P
q
©
ô
B�Òíó FòdÝÝQ|5Þ â )åÌ
æëÍÏÛ#¢¶YMµ íÂÐÚsÐ/Îâ
ãkDÜ&Yý
 =
i”íïœOUq  L ” Æ ñ0GcjpÿÉ m ‡ ½ ä TÁI¢,5(	a	o	WsþF‰f¨a Ù ò )J}»	

zv3cê ¡/¾c‚…\_„°Üß=áè/Ò¬[Á  = Éû§H©š	âþp{‡’ÕX”ÓG" t•ÇË9¯‚ÐÕ>öxÄ"=Jnó	šêCñ[W2¼c¸€öú½ " 6 ‹ ÿçTŒÒ
të—U¤À6Jañgv×†ù; î¤Ûš�
ea`Ž÷²èy¸Ô  { ° Z½E»dÅûó+Ñ_­É2m’ç
 ¬&hÞ--ü· bû+k³Gþ®ä,l×{D³& q’vm˜›¡¤»Ñå*p±SlÕðH¶û; £»òTÞqýðå^qð Å´`Ú×	1
³
�r#7®·ÌTÑâFVnõt« ; ‰ùÇã¹˜	Ðèan…ý)Ð¶�Ç3ÒE R¢	Ø
Î(„ð;Ùáû'F±¹ù(,Ü2Å2àD‡+ Ö Gz0kŒÀ=wWž§ý Î`	 ^	ˆ
‹
Lšåñôø<@ÆQ³ö a)î -4ât �º1i;pzèVÄ	­
Ö
¹çJcì›=× ÷ÝV'5OS7©ÛJ.n ÑÕÒv
ä
+’-u3M�æT‡tÿ‰1 \ 5Ý:zöÔú@~ÿA	Z	;°%] ¦¿è`ãøÃ¯‘ª#I•¦±åýÌëƒÐž¡í( `NÒ6ÏT
[
a
ÛãnvþL¹ÂÖ	4é
‹9" §N�¬(Èú‚	Š	Ê	Ó	
Ú
Á£ôœ”ú`¯w•í±Ó'K“ …Äul„þ	L
ï
›yì4”(z$?ê†ã3" JMœÜ|º™=Do¯mªÌÒ]œŸ[€ø.{’­›ÈþR ™ í T¶²Ä{	¤	ß	 
Ä
û
6´×G†*:‚ªñ	]¤FÂi W ï8ª“]‡eòÕÛs3=žy£õ!,+ ) S c q Í ö $ün}Ÿá§ËNÐŽ
OVB†ßë=Žq}†’œ§»ÞÀNyø²ã% Ÿ ›¬Â)f÷°
ì
(I¾�AÞ 4‰ÂÞ$ØµA €çTvŽ™ê# ¸ôAåì83ü¢¶
¹
Î
ßú	~«¾Ñ§õ&,cYÈ*Hª� $fØµ	à
@Ã˜i.!SªOd% tÓÉ°‚‘ž 	Â	…cžÕ_­´êö2>ÊÐø
lô=Dá[Þ\ 2r?dÜK%ë')ÃÅêœ–û™«È jê/„% é�Ù25Šñÿ\t}òÿä²	j
NQÛÏ
ºÇ¼úBë„Jži?X HŽ’¼T@W”iíÚ	z
“zÚD‹(U£¶6( —X$YÈÞ¾™?
1TÉÔ€"ˆÍïF�•Ë á =srË÷ìÇåêñXLš§  “ ¼ Ø ñ (I|/+'	`	n	º	2hýEîˆ  ! 5 ÆÏ=þwGSb�‹	Ñ
s<ðZÔ–IðÖWÒ Y«Úcý­ã+^k±²% ‘Q ³ÐÙ¸ÍokmËÔï°ø:ÐáÏ+SsÛ�ï1ä2Cp†Ñ" /j‹¿¹üÿ:_yUu
‡
Š
¬
‘™	&tó;NbåI,s% 4„Ü9yM5'Çù�	Ò	
K
S
Z
`
:¯$¥ç_óš›Ââ"ì	
8’ ( m©�
Þ…�©÷-ðQô+ È×ä7�eû��Ÿ	´	Á	¯
Í
ß
?H„ŒªÔ^ˆ½ÁÐ¦@C©)àG©ÝS[- –#Ž‘»ÇÛ14JS‰ðs|êñ&éi
PSÈÚÎú	Æª»CÌîéET¢hÊ à ð ªÙF€Š	&	ÆgYéâü*DíW‡Õ°! .4Ø^·ø
_
t
9�®#˜¤Ý%ls¨ÊM9ÏörBo$ ÆØ3dr
^
$Ír‡§¼ÉÏ¥ºá)L†¨DF¡¨AZ  ÖéÄÅŸ×c¨©ªÍ~»Ì&'£¤ŒBCO2Eo ÝÞßàýþ N ×ê	ŒN³Ý	§	Î eŠ•³¼Çz@cm��fp= È ¼` kÙ*
4
«ÇK(ÔPm3ÙáŸÿ$ O � ³ „Àë
È;�=O¿	"	K	Æ	ç	IÏÓúTA‘Êä�Žøg  ~ œ Ç´æ¨	!sªÑdn„™œ!?L­>  }‹ÞØf€‹Z¶@  Øñdy›¢X’	�–´½ÈU{Œ¸cqËŽ g – Ü!÷
ø8±Qnôyñ  	 ó2a¨vÚôá'
¾
þ/È÷@…ÕÚ~ D É ö'�•½á€Êó!Bâ	 
+
Ø2åLwŒè24"k# Aë¡äNl
5
l
¬Á¦)I�L‡¾e}-â]* 1 P ´ 5i…ÁZÉ5ò”¾V<6ä×		x	Ç	è	÷	¦
Á
è
YXû:¬F’òk…�ùù ‚ -“D¸]îKPÖÀ#	«	
ÕÐ})9yåh¥Ñ7i< ‰ ì€˜;‚L	xtUBqË9! ë "o÷ŽªÂ>n|¸Û?	/
Ö
JÔ’ 	HQÄš™žLqéál 	 & ‘ � �Íg«ÒÜiÍÐ° B  ,ïÈDµïˆßç¿	¼
Ëø"Å…Žš@Mka®Û[ - / é *Y–â79c	©	to�€à 	[3	‰e«"’®!8?* u ª ý ·Gýè¾FžìðÜ	:
ÙîgŸ<JOâ¤*    Vcùkß[c ¿ ¤$®Ýª*	E	d
�)vŒŸ•S[·À�.:AØ ~Œ.7�i æqÄŸ%“R ]»XY‡	C
‚
	(µ|/�ØÝ£0:¹#  Ý æ �Ù�æïeœð	|
Ç
Ê
•|‚Q—É1MV�‚Å…¥ NdˆtŒ·)B¤ge	YUfp\äKd­Ìª J´òCzÃñ£¬S	q	“	ì	ó	•
fŸ¾u�‹´ÔWr¸�hJ  I Ã 
žÝ^Š5ø
|â?�®¡S:Vò h $
«tR~	þ
%º5\ñFˆÍ‹ y … ® R»R"Â‹ùD²-èõz — ô Lü	½9öO­wÆRo°I¡
 ™-V;wõâI
x
0"$†H0b ôÂb¦Õ9Û›�	�	(
Òöeø‚AƒŠÛ @ Û +L3~ûQ	½	A
¿
æ
d�ÿŽÉgÖË}7 T©À5	G
#´ Ê (–¾â]„Ëã	2|é5E3§‹#A$ Êô"K–,
W
¦· Aw³ E £ Ñ :Bâ�±Dhp–‘™C7	©Ù3Ÿæ5#5cÌ š÷Z�N
!
ýJuMx�ìY‰lÆ ` B[yÌO¥Ò
™
3ðOÖ*Ï¿k˜$™æv¼Ö^f% fÓW�ÿÔì&a…µå£
E/VË%‹§J¿fÉÌolãì:`— 0à‘èmÎ­¶ÂÓu¼~�,Å k ²×è¢®	6
m
-”öxP‚
MˆgÙü.”ŸÉÎ—& µ 6†Â Ê˜ó1H•%Sà‡åxÌ	/	j	ø	`ÉZ_ac~Q³ú]®]¦5 2 ¹ Œ[å*6Qøÿ‹¿GZ‰»=†ü7–µØ	<	H	�	é	
é
,YôÇÞ&Ggó‰œÎíÃúX j7À-Ó'W+²
§
ëüA†ô¦( Q Z Ô ExÏßuUk¹X	\	y	È	Â
M;µå1­	G“l�«¹Ôð…%œ©* ‰	êQaÁ¸	Q
ª
Áã~²àó*Q}�´&6=Ï( ?”¹/^L Öî×ù	$	å	r
õ
=Ž¬Ö!Š¢¨¿ÅÑG¡>âæ7ç¦ÞRï mEäïÀBe€†îC	…	€
ÓŒ:˜—²ÞÒ,_ßP ^ w ƒ ¬ ÿ .˜¹|ˆ_�O	¬	CîôŸ±zeÿDi8jÊ Ïi.Í	M	
?CÅÌÎÜ$%©·ÝV ã ÀH<
yub“ViìrNp Š Ê�õæ„<^ƒòÛÞáéz‘çêV£5Zfù“: í£*™j²FÐ¬ÈÖ1l �C¶· pø_Ö	0
×
'úEŸÄD <Ñö0ÍoÜã
KäÕð4
IRÅLëš¨Öþm ¦ÃtkÑ�«?}þ@	¢““'KyväêÏÒŠ â'2 Ì ì #îIµÛÃÏ¹Þ	Uêl›ÝZ¿Mrz�ý£ ž ö¬ÝÝ×	 NZ Ø“$h>
y•Ó˜'�   
   ’ X<Îý;]jðKVÑ± ' �PûY
jîÎPr -ãE¶ð%‰èÀ	]k¯Ün M Ç M]
§Ì#d}‰”Æqy†b�ANl1D   € ðšH€ùrT›µ?bÊ� C • ò1ãÉ à
½
ä¥ †v‹x!\ 0 ˆ ê !4íJ—©mã:ª	.
pÿGÃx¤6;ø . )+ÌZá68b	÷Ä ¯  ¾ ü UbE-)	c
íuRZž¿åpNáb å BsÂ£«d	p	X0t Š�Ä9g©I  H Â ó Qs${Š¹4C¬¯ ? Ú *K~Ô84	œ	¼	Ñõ"d !f|/ A°C\ƒJ�˜M
V
¨žë"@ eË
ÑwŠ»Ø#“ë9€–»Õ+e$ Ó DwÎþ0GÒ&ˆº¸ß*†w±Ë;	G	W	Œ	ó` bPÓï­\¥Â v « þ —¸é~Ÿ¿íd`…„	«âž =±C+^³Î É¢h¿Gƒ]ñ;
’ÚÝàè>Ehy�éUÇ0ÿeøÜ ¥H´jýÕ	Ý	¡ïKxyãÕü&1  W;×úü’—Ö\&Y  ™â$
¦ã\q|ˆ“¤0>Cw   3Ar¨làªìöÃY¾Â®H  > G Á dÊr‚IL›	�ÿ•ºÔd  v–ÈÍ¤³FgÑ%ÞÊü:	F	‘Dx�ò_TÿÆd]÷ûÛ%0 À :Ö@˜áq#K
œ¥ë£–X½Á%/=B­A uÌ£klƒ«?pÅop9	›*+,-w�Ž ¡¢\]^7\]¸¹º»¼üýþÄÅ—½Á;<[\�¼½¾¿ÙÚ$/% ¥ <¥ä°m„¬¯÷y›«Æ>qô	+	e
.8^3˜Ž¾¹Â‚À¾? ø è¬jZÛ‚94rÅ7&b�³õwØƒú¿ # ©±’!P°zU“?�õf
Ó
Ü
uÃ/j– h7)e …­�œ/			,	
8_¡VÁ™6@KN¡òº°ÁH<S! 7 Œ ¦ =¦ån®ÇEr	Ì	·5ì˜ç¥”¿½Ã‡M•@ ­2k#
ƒ
¶}:ØsŽî´xÙøéz¹ ¼­›éYD

Üf*ÆÞ¤c��Õ ïÜùZN
)0_b
ºa„³ûå ^¥ˆ	ž
[ƒ5Ù&8'1;öì„À Fªòç±¼qƒ˜2,Ò`®Æ“*è*  | ± Þ ‚¾Ú“ÆQw�{@Žö
g
Ë
Ý
Ä–ÆüRÊWk—XÊA¦fÈ  $ ç [‘²ð"Veñ	}
È
Ô
v}O�{n�ƒ¡çi8g œwƒfn””P0Nô3s†5 ‡†‰�,-	h	
Þ–šO[‹ÂÍnˆÈT O'®ëCŽw9.`7¢LI ie†¸ß€h
	ZÂýALó»®±¸«= ­>u*.�¥0	f	V¢Wgq]åe 8 ùKcoÄ¤Ÿ­ñ
;kvz�™¤Y¦ØµÀi § §¯æµü 0§È	í	ô	–
�LHíÿèŒ•Øˆ–" >;@ó,D{ò¯²µ	T	 
g´ÿh¯i|Õ¾X¹E�´A � \Fsr	”	Í	l ¸6°¹¿åî-6m‚ |ÄsNK  ŸÞ_ewž
n®‘
¢Ö;<]UÂßrÚù¾êóº ÞÓ¼Ô$
„
q~I·ï¼µ& Ø_{ñ J Ä r“ëÎ¼ 3l§›
ñ¾ÚúWyñæk) ‹6™œ¢¥Òù
}ãæ+@‚¯²îQTm·¬Ù[t�¨ü¡¤·T¯óÊ;þr, ½Úbq®u	ZS	Ð	Ø	´
ÿ
&¼Ým|‘?]Øg¸Îò‚ßãGWG‰›Œ Æ%~a2
6±$¯ÍUÒ0}öd!Q ¬µœÛêv	8“o#‘�¬ÎÖ i E
›¤=»sÑ+ÇQ¥mu ŠOS]#QäO
p
ó
ŒÑéòâ*E³¡cÜ{´ü4 † Sð¡	
Fboþé›ÈT` < Èú¦ÃI[¯™	o†1.Ñ»b·…F z ¯ ¼DúÝºú,*`ö‘Óæ : Æ—	Ï):q„ü(Gú'Ý1pµÆ 6P²Ú(-Sí3áˆ _M‰	ý	Ù
¾Úâ÷x_®”Á3è…J2 V b p ˜ õ ûSL¦M{£	Ÿ
5\˜…ñ<Fp|…‘›¦Ôžº)92<xš�Ç÷±xE¢Áh# š«·Áó(2¡ù3#-éõ 1=%R´b<Çæcu€˜é 1Gq�>WèX½
ã±	y
0M›ùAÇê‡I”.5 × 'H{.<aÊö_	r1ïÓ•™¦% lƒx¸Ÿ¨þ²ÏxJ
‰
Œ
æ„ò™Áò:a¯÷!,*Úïî+ã	1, ß ï ©ÇÖ"R{é�œ÷ž	h
®
Ì
Þ
8GƒÅ—ÇÓÙfùXèBËíÎBqÔgÉ Õè»ÃžÖ2jqÜ¦	
)
JºËlKn§ØÜ<  } › ² ƒ¿cx:|Æ<W‘	Å	×S©ƒ˜Y‹œ >¬ f ÛõŽ”§Aá	1÷ýd„|ó ,hY’4ñ·	ö	~
¥
À
Õ
ç
wXW|P«8‘Kj„èh8k % , A � è Þ¾	~ˆÊhªÌj~  t © ¶ üø#©9
�(6žhŸÃ£9% Ü M\€³îc‡WfR	ï	ò	B
Æ
É
ež 'PLT€oŽ×Ü¢/„ �Q	ªÁQ}	ý
õNç‡UHŠ U¥H
w
å
�³‚ 6 Ð go••6	¶I1@v44ˆŠb$ ±ÒV€ÖþÓx„´ç˜
¢
,“.Í$NµO	tË—û˜ÈÍå_uÄ% Y 6Þä)—¿÷ŠF…û•.	[	i	
_^ä}F›²\Íì„$¥)% ] ˆ{‡ã.ŽÕAB	ä	<‰¡§À¾Ä‹±°ß—á6–æþPŒî%ÉO Îô- 	i±aÄ«Õ$k4¨ŒBo’¶U Ë ;õ^ÌT&é3ù’êJ~§¾u€ÃÎÑ‰Ÿ¢C Oõ#X
x:ÜÿMJ âL\
Sx…auŠ´
Œ û a(ËìD-
b
/QäowÿMÃ8£5:÷ @P¯BÓ7�—ÐU
#‰§¸Ðô!B º×ê{. Ò Ci}‡¹·)vV	ƒ	‹	Ô	ª ç�aw°þxîB²ÔÍ F 2q�‘õ[Âv¹# ¤ ;ã¢jª²Ef—àošÉû8	
¤6ûÃ–À$Z»¬#.># ¨‘ O­’Di		Ë	
Û
Y¶ÂÚ4•5?M ²ô¼6¯(GdL” ¬1"
M
×)í%^	ëƒä ›ñÅv‚mv“O
pNœzWr@æfÇ4 †=…ê+g	vÝ•ZŠm‡Ç# ®ø[:?±´/ž¦	ÿ	ð
€þ:gjK¯¸í5yŽ£Xh{× dê�Ý	ÍÒ¦»Ó�
š
íP«Z§½Ù\¶ù®ÁÉ%ÿ½×j Ùap}u	Ï	š£»<l{>°×’ÍÐ�/P|"lš P CN\P¥ H®
o
ò
ñEá+n ÛšS_( 9 U a o úLKzÅ–	4—Epwo{„�š¥Ó^�“À™œ0´çwg &p‚¶·'1É°	/øîÀèñ09”é+;Ù~åí˜¥— e š î ¨Ôç Õ!Å¥	à	7F‚0ØI¨Íp{«Óòm;# + s � ¨ gµÿXíb†¶¨	î	õ	8
¤
Å
W&‡Kgžª�Âiƒ¢
j% Ï °UýP³¤æ|	—
¡
ü
µÌHMŒ² ?Ê–ú—ÇÌ‰ä^aGÃ! X ãÍô-Eó”S^hˆ½ÃŠ°Ôàj}½t‘¤µBN ú ?Aá"ˆÏóR„Pt‰þz-ö 1¡©|n¶u	U	
XµÁv4>Ÿ¿YuºF"- ð9<«’é°³o 9fi®·ÖÜÖ‚Æ  T n Øé`ÑGt	•	Î	n
�
–¢ºDzàì‘nƒ¼OÚ!/³™O' * d r Ž Î %´þo~O£¯	7
.÷±>çð/8~“�©Áhzù}–¡ÆËÒä ù  â¨Ìt!RWn8‡¼ÀQƒO‰sˆßýtM) l m ÷ ø ³ý]^_s	 PQm•¡¹7Cyº»��Næï.7r‡¨• ÅÊÏÐÑ˜L  /L  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                        "                                                                                                                                                                                                                                                                                                                +                                                                                                                                                     	                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            	                                                                   	                                                         %                            %                                                                                                    
                                                                                  #                   	                                                             	                                    
   	         9                                                      
         	                                       
   
            (   &      %         $   (         ‡   V               %      \                     "                                                                                                                                              +                                                                     	                                                                                                                                                                                                                    	                         	                   %          %                                        
                              #       	                     	            
 	   9                  
   	             
 
    ( &  %   $ (   ‡ V     %  \   s  t|  t¬  tú  y–  ~Š  „È¼ÎËW@* Xopã^!A¨ !X8Wiz×¥ ÀÙùú} ÒÓòSj"cÓ¢
$ºÒø@
þÏ›™,I%	ßS Í NÒbÏR{
{({
{{
({
T3{
ýJ S Í í q‰N˜›ž¡÷ý`»ÑÚÊ	ß;®ÌçJ}ÌÒªþ ¦ny4 Ç·b¶	à	ƒ‰®öS‹¤ë	c
te
¤ë	cteƒ¤ë	cte‹ë	ettë	ehÓc·ç	¢
$jãè0z~Ñ!³M‘«ã�{
}
lãàâ�{
}
w«Nwðá°¿¿IèAì¼zœ�É”/å‹�
FS¬}äµD0ÀµD0öÃ‘…cx ­  º=
¼~QÐÔìÙ¡	*,ƒïj¸ÛwnÓRy	Â
ù
²m[	�«ŠŠ.Õ<‰¡§6æ¨(Qx ­  ºK¡	ƒï¸vÅ[~À7Ì¥™
ÂÐsâ
&äýÐâ
ýØ`¬Î	�
ºz{� þbN{�ÐÎâ
)Üýy	Â
	ê	“
{�í
Œ"èQ}	ý
‡ŠM
	¡	ƒï¸•ROJÁo	s‰f1	ä–|%“;ËÌ o.Q¡	ƒïØà¸C@Ð`z{œ�Ôæì™Ù¡	ê	“
î
*N~,Aƒïj‹Jë3¸Û+z§òû•ì/×²ÍÅ@Ç,ÝœQQŠCçgXdâNÕ'P¶u	U	õ	�
¤
F^‚»÷W{>ç/ªÍÖ\iþ}~äå—Ò5Ì¥Ò™
Ø$Öi;Ä	›Ì¥™
Oªø­Èµ
ô:±þgm[ð8]±ã›
m[ægX	õ	¤
Wªi{�ÂÐsÎâ
í
)ŒÜ&ä"èýb‘}
{g~7gXÕ¶u	U	õ	¤
F‚WªiþÚI©èS NÝ¶Z	Ó	ªÕãô<OMâ$*FJsw­Èƒ²ê Ó(gXNP	õ	¤
Wªiâ~OJ7QHŠ'@ê	“
dZâIU«¶7n\×/1�
¥/Bµº]ïùz�™¤.Õû•<‰¡§6æì¨/×(þ‰
ò:+ÎŸŠÛ	Qlè ûâø
Æ >ûPÐJ=
â
ô
ûâþFý‘ò‰,QYPÍ	N
g
}
Æw{¯èÊbšÆ A†g±fÈN×;Áyª­ÈxŸÏæÁ!îã=Ì€×¬;ÌxæÁ!Å¬[@²ÇÍsœºÕÎj,xµ c³Ø (I|º	bã¥ üÔw¹Š'ê	“
-dZâI«Iðë	”
³ÓV·X ¶ã'E1”^øè0;~å—¤¬-Ý˜!œk:wž§ý Îˆ
‹
%åèñø‘ö I¦)îÐž¡âR a{|�žàæšÊ£NAB<½z¨âdé�	Ñ�
�
ì¼\Á½k¶	¨
AìÜPwƒNsaæ£½zkwž§ý Îˆ
‹
åñö )îâ:%èø‘I¦Ðž¡íb†î	Å
&K�ƒ“½U5Öw	9EñŠ5ø
|â?�®S:MmŸRk:Jw˜›ž¡¤§ý ÎÑˆ
‹
å%*±åèDSloñøÒ]‘œöû I £¦’ò)›îýÐž¡âqX d¶ãé�	'E1Ñ”�
�
^øìè0¼\;Á~å½—¤SÛ.nöÁ{·Ú>	™˜pà(–¾„|E#&Éî”˜¥õB[4Ôz¶ÕÙ=	r'ð	Ï³R	ò	ež€ñpˆÀ±ßPŒ%  7ß!2Iù	aBVÃkä,l{I Ã 
B-[;Oõ
ð0*3§VA^ˆñâ‘pÀ±ßPŒ%Êö™¦14ŠKû	¼vÅù¹)�ÒT n •	–nƒ/³vmÕ;TÞq™Y¡bütü¬ž$X’·ÅQ=»+Q`uöÓF‡o†ç�¼#
ƒ
;k}Þ–îO´“zÈ	Xµ4>ŸF6€ú³	>‹©À?(ßR= ” ñ0^ÉHN	š	Bíóþóÿ2d ”Ó•��ºÚ03Iˆï ORÅ©èSh
	Ló»®bü¬™YütXÅ^N	Bíóó2d¡ž$’·QJ˜›¡¤Ñå*±DSloÒ]œû £’ò›ýqÊö14Š™¦“¸]KÖ#	ÕÐå¥# ±!UÓ
u h7¤Ÿ­ñ
: Æ—	Ï):q„ü(Gú'Ý1pµÆ9 U a o úLKzÅ–	4—Epwo{„�š¥Ó^�“À™œ0´çwgq’vm˜›¡¤»Ñå*p±SlÕðH¶û; £»òTÞqýðå^qðÙ ò )J}»	

zv3cê4„Ü9yM5'Çù�	Ò	
K
S
Z
`
:¯$¥ç_óš›Ââ"ì	
8’R¢	Ø
Î(„ð;Ùáû'F±¹ù(,Ü2Å2àD‡Oõ#X
x:ÜÿMJI�ºå‹¶ð(A†	ë	{
�
”
”{.e³[ÓãJV¤¬·R |žà›Ê7±’z	Ã
ú
N†Ad³ÖCn®<ËÑÚ\
‘¬©â\ +dê�Ý	ÍÒ¦»Ó�
š
íP«Z§½Ù\¶ù®ÁÉ%ÿ½×j,hY’4ñ·	ö	~
¥
À
Õ
ç
wXW|P«8‘Kj„èh8k( R [ 4m|„žÜà9y›Êõ7©±Mƒ5Óù'’ÇÎùY	z	�	É	Ò	
K
S
Z
`
�
Ã
î
ú
:N~†¯À$A\dŸ¥³ÖÞçC_n…óš®<�›©Âë3®ËÑÚâù\mu�©ý
"H”¥¸÷#->‘¬°Õìü°Ë‚©âéð	&Q\�ì
8’ô +% , . 0 A ˆ � è ê !,4h)+Y’4ñ·ÌíJZ—©máã68:Þ	b	ª	¾	ö	.
~
¥
À
Õ
ç
wXW~ˆÊ÷Äp|ÿGPh«Ã8x‘ªKj„Ì¤è6j h~;¯ø8ky … ® R»R"Â‹ùD²-èõz<Ñö0ÍoÜã
KäÕð4
IRÅLëš¨Öþm }‹ÞØf€‹Z¶@ð9<«’é°³o 9fi®·ÖÜÖ‚Æ#sÒ@e¯ëµ
¸
ë
'½Þb}�Â@—h³ÉÏô÷+kóX� ™â$
¦ã\q|ˆ“¤0>Cwy … ® 0R»$4„Ü9fyØRàM‘è"5m'ÂÇù�	µ	Ò	
K
S
Z
`
à
:@‹¯$¥ÃÎçù_˜­¶ÂóšDi›².Â!âSÓ"-u¼èì~ªõOz	�
,8d’Å¼­›éYD

Üf*ÆÞ¤c��Õ  &~     ¿  r        r’šY%µ§ ¶’¶OÙ˜¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“=öðÓôC ßNá4m… þ¨ë@«oA±4X üNàûAŒ½õá1"íLÛ qx%Ø�a£Ï wG¿üD.ªñ Ó‡b«‡z×€<
,þ«ž£ÓW‚;Pþ#}B<†Ñ}¶�Ú¯¼ÃŠ�½GÐ  >û¾z€s÷ Ñòn¢Žß?®ßn`0ÃL0ÓìCßaFUG™*
‘D~PhA–øÚM4ã·Š«âëj¾QAÒ©¾­FW[z;znÖú; n·©mW÷]Æ­1º‰¼Ê|#�T²ê_~æâ¬¤¬ÙòTN ¸�S�`Fæ‰…òž1T_ªq*ÖºxV:FbÆ…¼¦:ûï Â†=eãL8S€È¬hQy�ññ5Œ¢—‘:½Ö8e)åa+lE4¡‘¦5EÓQRŠkž·ž®ònö¬YL´w*½"?Õ¦`5”]!AT�ªº@Â¥&»	™Šµëò§·[(¡-ºÂªþ€c†(e+PøÔ4
o( cÁa:€çÁ��—E”Hh«S¨â«®úö`…&®�ê�Ž�b¾ƒƒI›¸›ü`÷¡³ u¿2�C=Y‡ôP„�”5ƒ¯ÄèÄhõá`om½€s¾¥ò{Të‚ ^ÁuyŒWö‰±Ý;!9äåNjÔ_ÈStm†Á4Óðß=öM@ÄeØ=¶Ô¶3­B7`@ï!p÷±1<ÿœ@ßÑóÔáBP ÿãúÏ€vø¿í+bpïPùÈSÏ¿Çž…8¾¿Äµ 2^±2|‡ôûøÐpÄ­¹Ô!N3õëþñÃü–4QGØ¾ñ0bÄ3øP1SD8S…=çáQ÷çPõü�8ü3ç\µÛR�Û~ý×yßl�tœ\Ï<÷½ðÃ`q8�I0óäm–ÓÙ÷j$B©èêU_¿wïþá]•acZ(¢—¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¥•¢S)f¨¥ZÌ¥j¢•´íª¥õ�ñ[Vþ™[UGÄd
(¯J�u÷šT\�ï\µ@ÅWË›@ÆÞrÛ–Ôª �%MålùPÿ‘:SÃ ÄT1PLäàÔ‰0·8Ì—ßwóÌéc<ç@Ì´ Þ« V#0_ù¨©ª¹YÚÕ˜›ÎØGY†V:ÖY¡UøCEôâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cä:£TlmDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^5CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíCcñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?�^ÜÖ|ó9‡eTtYW7 ,¨­•Ì°¿@àÞâÆßÿhÖsó*ëê¿ß÷ÿÔ¬Pý³O\°4?�dûBžÙ™êF†¥^¶ªZ•A¹Q¾ªnØ}Vþ—!*²½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž/®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈNa3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ïc  Z  «  ¸  
�   Û       Ò®ZTR

BASE       ¼D  xÁA  „°Y%<0pþ³öXa5­"I%ÊªRQr.’˜,©R·-7©¶É”bFR¬ªŠ5r¥®Pké¤X6E!ÈEFkNÈdVaà
i +rI‹-M[!NU#jnÛ4ZI.dm›Kp\•V[3uÛnKIÀÕrB©k‰B--p1	”É*WÈV¸é´"ËµU®˜B(Õj«°t:§Ãm¦b+	m¡Ìm­¬h9ÑtâD™+b•‹ëÊév   �<AlignableSequences trimStringency="Medium"><Sequence name="Copied Sequence 2" ID="0" sortOrder="1" trimmedRange="0..578"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  '<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="14" name="BAX" directionality="1" translationMW="21210.55" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3437" maxFusedRunOn="3437"><Segment range="603-1178" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2721-2730" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="12" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5692-5739" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4168-4272" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3558-3679" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4482-4617" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="365-568" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="61-364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4274-4631" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3686-4141" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6068-6656" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="mCherry" directionality="1" translationMW="26722.25" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2727-3437" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="28978.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4666-5460" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="CRY2PHR" directionality="1" translationMW="57188.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3437" maxFusedRunOn="3437"><Segment range="1209-2702" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;binds to CIB1 upon exposure to blue light (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot;&gt;Kennedy et al., 2010&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;N-terminal photolyase homology region of &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; cryptochrome 2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="Linker" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1179-1196" color="#ccffcc" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>e7bdccda-a642-43da-a834-7fa0e977e870</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="1:35:41">2019.3.7</Created>
<LastModified UTC="5:4:48">2020.11.18</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  	<StrandColors><TopStrand><ColorRange range="1151..1153" colors="red"/><ColorRange range="1178..1195" colors="black"/></TopStrand><BottomStrand><ColorRange range="1151..1153" colors="red"/><ColorRange range="1178..1195" colors="black"/></BottomStrand></StrandColors>  &‘     Ã  „        „’šY%µ§ ¶’¶OÙ˜¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“=öðÓôC ßNá4m… þ¨ë@«oA±4X üNàûAŒ½õá1"íLÛ qx%Ø�a£Ï wG¿üD.ªñ Ó‡b«‡z×€<
,þ«ž£ÓW‚;Pþ#}B<†Ñ}¶�Ú¯¼ÃŠ�½GÐ  >û¾z€s÷ Ñòn¢Žß?®ßn`0ÃL0ÓÀ>Ä=ö`uTy’ ©Gå„o�¤ÓN;qA¸ª¾.¶ ‹áE*›àQ:Ô`�…u·£·¦ío¡Cºáûz–ÕuÜjÓ h›Ì§Â9ÕK.¥÷îa¾*ÊJÀ}Ÿ%Aà�r»ˆÕ9Önh˜_ ™ã@Õú§­k§�Ec¤f,h[Êc¯¾ú(cÖ^4Ã…1¨ŠÆ…�8a_XÊ)y »Ð`Mc†RžV¶ÄSJcT]5( ¹ëyêï&ïjÀ”ËGr«Ò#ða]ZfQEÒEHÑº«¤l*Qk°™˜«^¿*{q5²ŠÛ¬*¯è8b†Rµ�CAð¦ò‚<¨|ÙtYD†Šµ:Ž!Jºï¯`V XRjàÞ¨á¨!Ûè84™»€I¿Æq::[ó)Ô3Õ˜EIÙCX:üNŒF�^öÛØ;ê_'µN¸"ìW˜Åh‘ÛÓ²žNTæ­Eü…7FØlM?½ð³ß`„ÔA]ƒÛmA+c:Ô#vòq+±1ÏùÄý=N!õþ?¬øo‹þÒ¶'õœ…7üñÛüyèS‹ëü@ëR3!…ëpÃ ‡ÈAï¿�JÛ�Bã0ß^¿ï?ÉcE}€àûï'üAÃ?…µ4C…8PpÃÞqÎµ~uQOÈÓ�Ã>uË]µ(·ïÝq�öÈIÅÌñÏ{ß6‰Ô“1îFÙm=Ÿv¢D*žŽ¥Uû÷~ÿá~ÙV5¢Š)z*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºPÉZ%2–jŠU¬ÊVª)[NÚª_Y°Õoé•µQd|F@¡"Šô¨Q/y¥EÈõËTU|¹´`ýç!}·ùmJª ±òTÞVÁ•?ñ©¡À<1rEA@QSÀÎ@ÎH“sŒÉ}÷<Î–3ÎtËBê°b3ÿšŠš«•�­Y‰¼í„u—øec­ešPQ/„0T_N Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Cª5FÆÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãQÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô16?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬VSý~=·«÷Ï>¹…B€ë²«ÀsÃ�†ûÓ0íŽ®³÷ù åá]ÁAgÁA3˜pÖUGE•spŠÊŠÙ\À+ôî,gýñö€=g?2®¾«ýÿýJÀ…Ð;4õË ÃCøöO´)í™ž¤hjUëj¥©T�…ê¡–í‡Õoér«+Þ-òEQµAºèFúª¸Ì–ãŽ�]U_|çÓ**<Q9õîªñB^´Ñ3F}Yâúä‰<’�÷Þµ¸“|ùÙû;Ž[âŸH8ãÒe,‹§À {QÆJ|C4ÂÀáp ¬�Ý?N�1qùß„gçL„æS=Î¿T0t&ð”Ã@°]LÜ@N½ Ï‚n¦KâÀ«=û‡¡2Æª!ŽË@ù�UÏMsªœ+àú£ƒêŽÝŠêøÊoøkˆ|š|ö6  Z  «  Ê  
Ÿ   Û       Ò®ZTR

BASE       ¼D  xÁA  „°Y%<0pþ³öXa5­"I%ÊªRQr.’˜,©R·-7©¶É”bFR¬ªŠ5r¥®Pké¤X6E!ÈEFkNÈdVaà
i +rI‹-M[!NU#jnÛ4ZI.dm›Kp\•V[3uÛnKIÀÕrB©k‰B--p1	”É*WÈV¸é´"ËµU®˜B(Õj«°t:§Ãm¦b+	m¡Ìm­¬h9ÑtâD™+b•‹ëÊév   ‘<AlignableSequences trimStringency="Medium"><Sequence name="Copied Sequence 10" ID="0" sortOrder="0" trimmedRange="0..578"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  8<?xml version="1.0"?><Features recycledIDs="0" nextValidID="16"><Feature recentID="15" name="Linker" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1179-1196" color="#ccffcc" type="standard"/></Feature><Feature recentID="14" name="CRY2PHR" directionality="1" translationMW="57188.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3455" maxFusedRunOn="3455"><Segment range="1227-2720" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;binds to CIB1 upon exposure to blue light (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot;&gt;Kennedy et al., 2010&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;N-terminal photolyase homology region of &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; cryptochrome 2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="NeoR/KanR" directionality="1" translationMW="28978.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4684-5478" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="mCherry" directionality="1" translationMW="26722.25" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2745-3455" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="11" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6086-6674" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3704-4159" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4292-4649" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="61-364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="365-568" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4500-4635" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3576-3697" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4186-4290" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5710-5757" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2739-2748" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="1" name="BAX" directionality="1" translationMW="21612.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3455" maxFusedRunOn="3455"><Segment range="603-1196" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  A<Notes>
<UUID>e7bdccda-a642-43da-a834-7fa0e977e870</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="1:35:41">2019.3.7</Created>
<LastModified UTC="6:30:18">2020.11.17</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  <StrandColors><TopStrand><ColorRange range="1151..1153" colors="red"/><ColorRange range="1178..1195" colors="red"/></TopStrand><BottomStrand><ColorRange range="1151..1153" colors="red"/><ColorRange range="1178..1195" colors="red"/></BottomStrand></StrandColors>  $2     Ã  �        �’šY%µ§ ¶’¶OÙ˜¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“=öðÓôC ßNá4m… þ¨ë@«oA±4X üNàûAŒ½õá1"íLÛ qx%Ø�a£Ï wG¿üD.ªñ Ó‡b«‡z×€<
,þ«ž£ÓW‚;Pþ#}B<†Ñ}¶�Ú¯¼ÃŠ�½GÐ  >û¾z€s÷ Ñòn¢Žß?®ßn`0ÃL0ÓO±}…Ud¨*EùA¡[ãi4ÓŽÜPn*¯‹­¨"øQEJ¦øNµ a]mèíé»[èPî�¸~Þ¥µ_Ýw´Æè&ó)ðŽuRË©}û˜oŠ²’°gÉPE8 \€nâ5Nu�š&ÈfxÅP5~©Ä«ZéàQXé‹ò˜ëï¾ƒ
õ—�0áLj"±¡EäXCÄWÄÖ2Š^Dè.ôXá”§•„­±Ò†F˜ÕMEJ(®zÞz»É»Ú°e2ÑÜªôˆüWV™€ÔFQt…QR4nªé [
”Dšì&f*×¯ÊžÜMl¢„¶ë
«úŽ¡”­CàGPÐ|)¼ ��„DêŸ6]Q!¢­N£ˆR®»ëØ€š¸wª8jˆvú&nàoñƒÜN†Î�ÖüÊuõfÑBvPÖ¿££×…�½¶öÎú—ÉíS®�{Õæ1_Ú$vÇtì„ç“•9«Q!MÑ¶ÓOÀo|,÷Ø!5A—`öÛPJØÎµÝ�¼…ÃÜJÄl@Ä@óþqGÏS…}@ƒÿ�ë>Ûâÿ´­‰Ã½Cç!Mÿ<vÿzâúÿ:Ô€LÈazÄ0È!òÐ{ïãAÃ¶çP…8Ì7×¯ûÇòXÑE`8>ûÄÁ‰ÿpÏá@ÄmMáN0÷œs„-Gß�CÔSò4ãðÏ�r×mJmû÷\Aç}²Òqs<@óÞ÷Ã�Äâu$ÃÌ{‘¶[OgÝ¨‘
§£©U~ýß¿ø_…vU…�h¢Š^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn”2V‰L¥š¢•k2•ªŠVÓ¶ª—ÖCÅl5[úemTY�(H¢½*ÔKÞiQr½rÕ_.m?yÈ_mþ[Rª€,B<•7•°_å@OüjDèpO\ƒPPTÅA03�3ƒR$ÂÜã2_}ßÏ3¥Œó�2Ðƒz¬XŒÁæ¢¦ªågkVbo;aeþXëYf…TKáÓˆ"-) T¿ÐïôÐÑI�ScnÖ’Ó_B T¿ÐïôÐÑI�ScnÖ’Ó_d¿?åï?oÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª��ê�Q±µÐaÊ³a¡u74+¼<èkaà7]l8îóÈ¯-3@3ð®ª-GÇâð�áaxÔq3lƒƒÜp2¾ŒÓˆìr‹xS@x8æ€Å#À4¾-»~Žøñ&öØ8cXÃ6s¡¼9øý¬}õ1]³lLMÉìðº,m�Åm ìÏOŠÏCµM�ÇA»,‡öcã£Å›`�V:®¶Çˆ<8ƒÎmdÊ!š8Q:1`8|ëìŽ§	³Îük4Í³ë›>ºJë„À{€+‡ÇÔÇ?_�mÄjÆ½óÏ®aP :Álªððàa¾ôÌ»c�+¬ýþ@9xWpPGYðP_Ìæ5•QÑe\Ü"€²¢¶W0
Âýƒ{‹ÿ|Gý YÏÌ«¯ªÿßÿR°!CôÍ=rÀ0Ðþ=“í
{fg©•zÚ©jUä!Fú¨e»aõ[ú\„ªÊ÷„ËGü‘TmPnº¾ª®3%¸ã£WUWß9ôÂ
Š�ÔN}{ª¼P—ƒ­4LÑŸVx¾¹"O$¤=÷­Eî$ß>v~Îã–ø§Ò8ôƒK"éð(Ôq’ŸPÍ0°8\ +#wOÓ L\~wÅáùÓ!9„TÏs¯Å	¼%0Ð,A7¯@sà›©’ø°*Ï~áèL±ªˆc²Ð Á>`UsÓ\Ãê§
ø>¨àú£·bº¾2›þâ_&Ÿ=�  Z  «  Ç  
œ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  '<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="14" name="Linker" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1197-1211" color="#ccffcc" type="standard"/></Feature><Feature recentID="13" name="BAX" directionality="1" translationMW="21612.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3452" maxFusedRunOn="3452"><Segment range="603-1196" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2736-2745" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="11" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5707-5754" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4183-4287" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3573-3694" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4497-4632" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="365-568" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="61-364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4289-4646" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3701-4156" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6083-6671" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="mCherry" directionality="1" translationMW="26722.25" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2742-3452" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="28978.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4681-5475" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="CRY2PHR" directionality="1" translationMW="57188.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3452" maxFusedRunOn="3452"><Segment range="1224-2717" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;binds to CIB1 upon exposure to blue light (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot;&gt;Kennedy et al., 2010&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;N-terminal photolyase homology region of &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; cryptochrome 2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  A<Notes>
<UUID>e7bdccda-a642-43da-a834-7fa0e977e870</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="1:35:41">2019.3.7</Created>
<LastModified UTC="1:53:12">2020.11.17</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  #_     ¿  r        r’šY%µ§ ¶’¶OÙ˜¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“=öðÓôC ßNá4m… þ¨ë@«oA±4X üNàûAŒ½õá1"íLÛ qx%Ø�a£Ï wG¿üD.ªñ Ó‡b«‡z×€<
,þ«ž£ÓW‚;Pþ#}B<†Ñ}¶�Ú¯¼ÃŠ�½GÐ  >û¾z€s÷ Ñòn¢Žß?®ßn`0ÃL0ÓìCßaFUG™*
‘D~PhA–øÚM4ã·Š«âëj¾QAÒ©¾­FW[z;znÖú; n·©mW÷]Æ­1º‰¼Ê|#�T²ê_~æâ¬¤¬ÙòTN ¸�S�`Fæ‰…òž1T_ªq*ÖºxV:FbÆ…¼¦:ûï Â†=eãL8S€È¬hQy�ññ5Œ¢—‘:½Ö8e)åa+lE4¡‘¦5EÓQRŠkž·ž®ònö¬YL´w*½"?Õ¦`5”]!AT�ªº@Â¥&»	™Šµëò§·[(¡-ºÂªþ€c†(e+PøÔ4
o( cÁa:€çÁ��—E”Hh«S¨â«®úö`…&®�ê�Ž�b¾ƒƒI›¸›ü`÷¡³ u¿2�C=Y‡ôP„�”5ƒ¯ÄèÄhõá`om½€s¾¥ò{Të‚ ^ÁuyŒWö‰±Ý;!9äåNjÔ_ÈStm†Á4Óðß=öM@ÄeØ=¶Ô¶3­B7`@ï!p÷±1<ÿœ@ßÑóÔáBP ÿãúÏ€vø¿í+bpïPùÈSÏ¿Çž…8¾¿Äµ 2^±2|‡ôûøÐpÄ­¹Ô!N3õëþñÃü–4QGØ¾ñ0bÄ3øP1SD8S…=çáQ÷çPõü�8ü3ç\µÛR�Û~ý×yßl�tœ\Ï<÷½ðÃ`q8�I0óäm–ÓÙ÷j$B©èêU_¿wïþá]•acZ(¢—¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¥•¢S)f¨¥ZÌ¥j¢•´íª¥õ�ñ[Vþ™[UGÄd
(¯J�u÷šT\�ï\µ@ÅWË›@ÆÞrÛ–Ôª �%MålùPÿ‘:SÃ ÄT1PLäàÔ‰0·8Ì—ßwóÌéc<ç@Ì´ Þ« V#0_ù¨©ª¹YÚÕ˜›ÎØGY†V:ÖY¡UøCEôâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cä:£TlmDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^5CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíCcñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?�^ÜÖ|ó9‡eTtYW7 ,¨­•Ì°¿@àÞâÆßÿhÖsó*ëê¿ß÷ÿÔ¬Pý³O\°4?�dûBžÙ™êF†¥^¶ªZ•A¹Q¾ªnØ}Vþ—!*²½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž/®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈNa3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ïc  Z  «  ¸  
�   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  X<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="13" name="BAX" directionality="1" translationMW="21612.91" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3437" maxFusedRunOn="3437"><Segment range="603-1196" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2721-2730" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="11" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5692-5739" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4168-4272" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3558-3679" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4482-4617" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="365-568" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="61-364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4274-4631" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3686-4141" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6068-6656" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="mCherry" directionality="1" translationMW="26722.25" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2727-3437" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="28978.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4666-5460" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="CRY2PHR" directionality="1" translationMW="57188.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3437" maxFusedRunOn="3437"><Segment range="1209-2702" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;binds to CIB1 upon exposure to blue light (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot;&gt;Kennedy et al., 2010&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;N-terminal photolyase homology region of &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; cryptochrome 2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  A<Notes>
<UUID>e7bdccda-a642-43da-a834-7fa0e977e870</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="1:35:41">2019.3.7</Created>
<LastModified UTC="1:52:36">2020.11.17</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  #D     ½  l        l’šY%µ§ ¶’¶OÙ˜¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“`p/ M?D0 ýôîFØQÐêŽ´
¶ô@Å€ ßÄàþð�´ËßQN.ÔÍ°�Ò]�8Ñ<òt{ÿÄBê¯8v*¸p×­xÀ¢Ïê¹ê=5x#µâ7Ô#ÁxmÛ`8 zûÀL8 8Ô}
Ãï»ç¨?r!öê ÀHíóúíöàQF4Ã>Ä=ö`uTy’ ©Gå„o�¤ÓN;qA¸ª¾.¶ ‹áE*›àQ:Ô`�…u·£·¦ío¡Cºáûz–ÕuÜjÓ h›Ì§Â9ÕK.¥÷îa¾*ÊJÀ}Ÿ%Aà�r»ˆÕ9Önh˜_ ™ã@Õú§­k§�Ec¤f,h[Êc¯¾ú(cÖ^4Ã…1¨ŠÆ…�8a_XÊ)y »Ð`Mc†RžV¶ÄSJcT]5( ¹ëyêï&ïjÀ”ËGr«Ò#ða]ZfQEÒEHÑº«¤l*Qk°™˜«^¿*{q5²ŠÛ¬*¯è8b†Rµ�CAð¦ò‚<¨|ÙtYD†Šµ:Ž!Jºï¯`V XRjàÞ¨á¨!Ûè84™»€I¿Æq::[ó)Ô3Õ˜EIÙCX:üNŒF�^öÛØ;ê_'µN¸"ìW˜Åh‘ÛÓ²žNTæ­Eü…7FØlM?½ð³ß`„ÔA]ƒÛmA+c:Ô#vòq+±1ÏùÄý=N!õþ?¬øo‹þÒ¶'õœ…7üñÛüyèS‹ëü@ëR3!…ëpÃ ‡ÈAï¿�JÛ�Bã0ß^¿ï?ÉcE}€àûï'üAÃ?…µ4C…8PpÃÞqÎµ~uQOÈÓ�Ã>uË]µ(·ïÝq�öÈIÅÌñÏ{ß6‰Ô“1îFÙm=Ÿv¢D*žŽ¥Uû÷~ÿá~ÙV5¢Š)z*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºPÉZ%2–jŠU¬ÊVª)[NÚª_Y°Õoé•µQd|F@¡"Šô¨Q/y¥EÈõËTU|¹´`ýç!}·ùmJª ±òTÞVÁ•?ñ©¡À<1rEA@QSÀÎ@ÎH“sŒÉ}÷<Î–3ÎtËBê°b3ÿšŠš«•�­Y‰¼í„u—øec­ešPQ/„0T_N Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Cª5FÆÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãQÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô16?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬VSý~=·«÷Ï>¹…B€ë²«ÀsÃ�†ûÓ0íŽ®³÷ù åá]ÁAgÁA3˜pÖUGE•spŠÊŠÙ\À+ôî,gýñö€=g?2®¾«ýÿýJÀ…Ð;4õË ÃCøöO´)í™ž¤hjUëj¥©T�…ê¡–í‡Õoér«+Þ-òEQµAºèFúª¸Ì–ãŽ�]U_|çÓ**<Q9õîªñB^´Ñ3F}Yâúä‰<’�÷Þµ¸“|ùÙû;Ž[âŸH8ãÒe,‹§À {QÆJ|C4ÂÀáp ¬�Ý?N�1qùß„gçL„æS=Î¿T0t&ð”Ã@°]LÜ@N½ Ï‚n¦KâÀ«=û‡¡2Æª!ŽË@ù�UÏMsªœ+àú£ƒêŽÝŠêøÊoøkˆ|š|ö6  T  ¥  ²  
‡   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ?<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="13" name="BAX" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3431" maxFusedRunOn="3431"><Segment range="597-1190" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="12" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2715-2724" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="11" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5686-5733" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4162-4266" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3552-3673" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4476-4611" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="365-568" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="61-364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4268-4625" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3680-4135" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6062-6650" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="mCherry" directionality="1" translationMW="26722.25" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2721-3431" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="28978.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4660-5454" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="CRY2PHR" directionality="1" translationMW="57188.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3431" maxFusedRunOn="3431"><Segment range="1203-2696" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;binds to CIB1 upon exposure to blue light (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot;&gt;Kennedy et al., 2010&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;N-terminal photolyase homology region of &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; cryptochrome 2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  A<Notes>
<UUID>e7bdccda-a642-43da-a834-7fa0e977e870</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="1:35:41">2019.3.7</Created>
<LastModified UTC="1:51:10">2020.11.17</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  !h      %  *        *’šY%µ§ ¶’¶OÙ˜¼Êv^œ%`üø8|ýqÿÏÚµ–˜¯Ù%ÏYêö‡-` I©ÂW�ÞƒIÛR&Ù�Rsÿšµ‡	X?>¦?IØ~˜«ç Òvç&’Û9§Ø!Œ*ƒIÛX�“
‡· jõ.÷ý¡ËX¨ªõ[\«ÕbÉuï?ÚÕ€ÂC"p€Bæe4N
’ËFó“9ð{FìCßaFUG™*
‘D~PhA–øÚM4ã·Š«âëj¾QAÒ©¾­FW[z;znÖú; n·©mW÷]Æ­1º‰¼Ê|#�T²ê_~æâ¬¤¬ÙòTN ¸�S�`Fæ‰…òž1T_ªq*ÖºxV:FbÆ…¼¦:ûï Â†=eãL8S€È¬hQy�ññ5Œ¢—‘:½Ö8e)åa+lE4¡‘¦5EÓQRŠkž·ž®ònö¬YL´w*½"?Õ¦`5”]!AT�ªº@Â¥&»	™Šµëò§·[(¡-ºÂªþ€c†(e+PøÔ4
o( cÁa:€çÁ��—E”Hh«S¨â«®úö`…&®�ê�Ž�b¾ƒƒI›¸›ü`÷¡³ u¿2�C=Y‡ôP„�”5ƒ¯ÄèÄhõá`om½€s¾¥ò{Të‚ ^ÁuyŒWö‰±Ý;!9äåNjÔ_ÈStm†Á4Óðß=öM@ÄeØ=¶Ô¶3­B7`@ï!p÷±1<ÿœ@ßÑóÔáBP ÿãúÏ€vø¿í+bpïPùÈSÏ¿Çž…8¾¿Äµ 2^±2|‡ôûøÐpÄ­¹Ô!N3õëþñÃü–4QGØ¾ñ0bÄ3øP1SD8S…=çáQ÷çPõü�8ü3ç\µÛR�Û~ý×yßl�tœ\Ï<÷½ðÃ`q8�I0óäm–ÓÙ÷j$B©èêU_¿wïþá]•acZ(¢—¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¥•¢S)f¨¥ZÌ¥j¢•´íª¥õ�ñ[Vþ™[UGÄd
(¯J�u÷šT\�ï\µ@ÅWË›@ÆÞrÛ–Ôª �%MålùPÿ‘:SÃ ÄT1PLäàÔ‰0·8Ì—ßwóÌéc<ç@Ì´ Þ« V#0_ù¨©ª¹YÚÕ˜›ÎØGY†V:ÖY¡UøCEôâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cä:£TlmDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^5CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíCcñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?�^ÜÖ|ó9‡eTtYW7 ,¨­•Ì°¿@àÞâÆßÿhÖsó*ëê¿ß÷ÿÔ¬Pý³O\°4?�dûBžÙ™êF†¥^¶ªZ•A¹Q¾ªnØ}Vþ—!*²½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž/®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈNa3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ïc  p  E   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  û<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="12" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2137-2146" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="11" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5108-5155" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3584-3688" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2974-3095" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3898-4033" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="365-568" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="61-364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3690-4047" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3102-3557" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5484-6072" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="mCherry" directionality="1" translationMW="26722.72" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2143-2853" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="28979.67" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4082-4876" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="CRY2PHR" directionality="1" translationMW="57190.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2853" maxFusedRunOn="2853"><Segment range="625-2118" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;binds to CIB1 upon exposure to blue light (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot;&gt;Kennedy et al., 2010&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;N-terminal photolyase homology region of &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; cryptochrome 2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  A<Notes>
<UUID>e7bdccda-a642-43da-a834-7fa0e977e870</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="1:35:41">2019.3.7</Created>
<LastModified UTC="1:50:52">2020.11.17</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  ,ý7zXZ  æÖ´F !   t/å£àŸ;
ê] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉFšõt$ÞÞ2ºérx+§õíÓäaGg�–¬eÎÇní)HêË½‡RŒÊ!ÏQÄ\Ú…KÓIˆ2ÁFÅ
û¹|T`[æ­çÁ_ð>Ö,±ù)¹Ÿžá² +ŠØ�›Á!±|~xçQÕ¤9»�­b:*(K¾Æ’|òU’¾Æ5<®2ÆX >�2Èœ´À·âƒs± GÒblúÊþut#äŸ¸_LW%êâQÅŠf6*ºÍVÀ«Wú).X—ª
ãˆž0½ƒ&äwÆÛÛFÍìƒ=æZ<¡ÎàzúÖnò4®¿$×»sCÕùš§}£€ôšçÚ’†§¨i‡1—É„¿¨w�züEÅQ€M�@lS0ŒTg_èVeß‡K´GGàÑàÊ ¶Y
È"ã»®I~¹ó_9BÏLžLmñçû#�°FöZ¥¼†	„þÓA1þØáìæ´§w‡ýÛ
…ÞÓ»kn:%…þI5A¸'v¹„½ù0ì¢ÿRuìŽ 5èKÊÍ£EÚP foùvÝ o×¹Yµ�ÁÏU§CTíû,ÐÇ<we]2È�Ü‰‹ˆmG&Œ~kåioÖhpãûš£/Ïùž	¨…ù•£ÂjÌ¡WnÔ>Tlz¡Ê§g¿cs0¾ºŒÈ�"š	¯ft.ÍÂs¶Y¬%Ï¾+?9™¿¤Í�Fí#š	—„€ ã`jQ¼ÃÒ€‡à¸Â‹sð³è²¤?&7þ$šP÷b©� ™oÃÒl°*Î~!°!*ñ”¦XøyüzƒOüp7sÊWkkŸÝ¸‡ÀÛÐÉïµ�läÍžAgÝÂ_Û-åû¡j—¯øsî7´ÏÚS <‡ß7óòÞþÏŽä|+ù¡zY^û©�·}6®«4ŠŠ!ó‚p$.�í ˜�}ó¶JÖ›[)œ{r’<âwô]´»;0¸QÆêœDA"3\&iatš&x×Æg�Ç�¸ánÃ®›Q5ªÏ\òƒ31úMãöüŸNETÄ4uòöo‹¿çæyÁ:‘{)¾ú0:ìÙVNØ?b#C;D�<hyŸäâ±²ÁÇ’¶HŸI�¥*CœËŸŠ_�ØùR:ÀÕh�¯ææ5‡±–`}´#®qÏ}[`p5IŒAŽþ¦3	á¤ßód‰	xòKç_fjz¢=†Ì¡Dv[M®8ð—´éúIÒÊæ" ¯F<(urûºÓ�ŠA‹PÏï¤`)±ê^îãª3cò ÔÆM(‰‚¬7n‹éZjk›­¦*?~ÙÒ˜Å±mbÛÂCp½ Ù¹’<Ò7”Ûß<oxOýÐuøe`¨P„ñý§7¨£QÉ»oG ¢.w
þñ�Þ„aé§÷‘Â€'ÀŠºÈóéü¢Átµpã��~Š¦Þ…]¼“Šöžì3‹Ù
ÀÌ“$ØÎ…u»nL³Â3´EœU�þ$A?¦ÞSî]ó'Æf Ö¼ïi5JxÔØYS;ä!Ï†Û…gWÏ¼!Å“ˆ£Ô¯Q*½ïÎ®éÜ…àîã™I_cqM€@ƒ°KGþ—1<-¶•Ès3Môª»——DÝ©ïÄ½ßN#-¯0ˆ�§ñ…Ù5¥ë^1,/‰WåÕQ{Š„ÓL2îObéöFn„¹ìÐ1ÿ’(A3Öð-Ö™þb±nš82Äß|9ÕÈÕah³ƒj-�lpÞ<ñrÇl~=a,zÎH”/Žïù	433`6Ã¯ÞÚhûßh£Ç¡AZ	+Ç¾ôªkPYÊ3eRÚß\o>Ê±h#Å÷=RÈH»ñéÔz{ë®ÂŒ7sé’=&ç(u($õer·eìçDæ÷˜AÊˆd�XÒ½®p›S
êz=¼5å\þ²Â†°†"îî‰Æ…RLŒ‹€
‘�ï‚”H¹ùo(—-clÉ8¬ÈüX«ã¤°¹ñl‹{'€3Tj{ÁÑõë`œÁ¾Ôí­Òà¦°œ”7#:Ò_Æ,$2`sh6“Q:†zá9Sg‰Oƒe‚@! kF-¶”œ‚KÌæd¦¤wüR,ïžwwi
,fÜjÌ)�_š‚ÛæX#ÜÖ0Ÿ?ì¯b•ú:‚†@úì›CVMn{´×ŠÞiÇöÁ�³Lý*Â)|OÄ7
<uó¶´w£oS–1þ;O€ˆ=Àøö`‚6¦Lî¿×_S†uq”=R¤ßê4DŸ!SÙiw.Åˆ
5¦–6<õôkˆýŸBNÉw;t9‡íòF.ŽÞ¡6*u—&S -ˆeb8iÁZùwš×ùŠ¶‹@¼�¾ÎEÅŸAÐ‰"ùföi´ÎÙ'_£(Æ·ÚÚ�R7t¶›!=òÓˆéŠp3MÔòå5<¥!¼Ã}•‹×Yœ÷üü€½,ßiçtnÇE�´Tû–[N1»� ßµ‹|Ì%ÆÒÀKß‚Ún¾Ø)”w“0zFmŸÑQv>/*õØ¼-QzÞCs§qª;£¸{æÄÝé¤‘I<î!%Žv2¦&d�EÈ§Éõ$–ã¨BÒÒÉJL‰Ð`q%/Ï}èéî%î‰¯¼¿‚hÂÌSWŠù.6¼Nf³%ðtÕ4ÛL™2°´Mü1NA½ 1‚’oí¤|íTå�4":%&ÔeÌŸ]yÄítù±›Eiì+BibonRÌeÀ¨løXðKLÐÿæf½Ó]Gž¹Î@a­ÂÖV»£E:wÓ¡<E“/5C'æˆç§Ám[4&±‰è(?|SS¢{æýXhñï7S»ÏÙmå**ºÐ¡	Pd9Úâ@:uv…^àºY;`^á×¯Rž¤úu0äÍÄ×y“ªh»” -×å�5¶¡ã¥OÉlDˆÙç­TØ³—wåêÅ\iÓÛóÒÓ¿ÁI‘òhç„ÖÊµº†º¼{Vï^X
nœfä“Ô.Æ,´Êtð¯ú³xå1¿f p*(·@ÐR
y95)Hhêí{ÚìèX`y–´ŸY'I¹º|� xúó§¾ýÒJmÎýÂ¿H$Rýêú«í©†f%é²óX+,4%õ“†ù�M-ƒ#Ç�,wÕ«Úx¢ùsÕýW„\N%eúÙ îþ­ì¶ß��×4Ër-2y
¤H¢ë�7ˆ¬¢½ZÕ§êœªmðÜ[…_,Lò@DçD¶<Ë“æEauÌ]ËÈùÑüÍ°èU³¥ò|Ün%ò[Ä‡NÀ€™Ðè¥gYÌÊ(ðÅ“ˆ­Ò¥¦†/ëwÁ:ðVoj¢èü:2ÀÆ\˜y–×3:SÃÞAÃ)ï­S´xŠc�‘hËp¥îšýÀ»oÆ=Û¿m�0�”PžÊÃžŠN1!	Yw”Ø|¹€‡cy¼ÚÝøLûÃÊTiÍe8‚gÎÍ‰æËñÄÝ \«À02ƒmýÓiÚ…Œb#•{Ù9L‚LxÞO$2ØjaöÈÒlë¶zÌÀ"¿ëcã]”IížM•k-1�àçgÆY!í£å-lœ…«õ<ÓU„Øñå§_xùœch»JUPºŸÂæ¿ÞQdê©Œ³~-S¤”ü>à+ŠÊ0£"ƒé¯À,O&_ó�/ìÏ+„b¦ƒYHÖâ(’µ
<Ï§ã$´²÷0}úÞò\    [MéfÀ+Ä: †¼¾ €NN±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  g<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="0" name="Linker" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1179-1196" color="#ccffcc" type="standard"/></Feature><Feature recentID="1" name="CRY2PHR" directionality="1" translationMW="57188.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3437" maxFusedRunOn="3437"><Segment range="1209-2702" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;binds to CIB1 upon exposure to blue light (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/21037589&quot;&gt;Kennedy et al., 2010&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;N-terminal photolyase homology region of &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; cryptochrome 2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MKMDKKTIVWFRRDLRIEDNPALAAAAHEGSVFPVFIWCPEEEGQFYPGRASRWWMKQSLAHLSQSLKALGSDLTLIKTHNTISAILDCIRVTGATKVVFNHLYDPVSLVRDHTVKEKLVERGISVQSYNGDLLYEPWEIYCEKGKPFTSFNSYWKKCLDMSIESVMLPPPWRLMPITAAAEAIWACSIEELGLENEAEKPSNALLTRAWSPGWSNADKLLNEFIEKQLIDYAKNSKKVVGNSTSLLSPYLHFGEISVRHVFQCARMKQIIWARDKNSEGEESADLFLRGIGLREYSRYICFNFPFTHEQSLLSHLRFFPWDADVDKFKAWRQGRTGYPLVDAGMRELWATGWMHNRIRVIVSSFAVKFLLLPWKWGMKYFWDTLLDADLECDILGWQYISGSIPDGHELDRLDNPALQGAKYDPEGEYIRQWLPELARLPTEWIHHPWDAPLTVLKASGVELGTNYAKPIVDIDTARELLAKAISRTREAQIMIGAA"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="28978.79" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4666-5460" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKASMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="3" name="mCherry" directionality="1" translationMW="26722.25" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2727-3437" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;monomeric derivative of DsRed fluorescent protein (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/15558047&quot;&gt;Shaner et al., 2004&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEGTQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDAEVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHSTGGMDELYK*"/></Q></Feature><Feature recentID="4" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6068-6656" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3686-4141" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4274-4631" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="61-364" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="365-568" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4482-4617" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3558-3679" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4168-4272" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5692-5739" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2721-2730" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="14" name="BAX" directionality="1" translationMW="21226.50" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3437" maxFusedRunOn="3437"><Segment range="603-1178" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTAELTIWKKMG"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¯<Notes>
<UUID>d4ba6055-4ede-4d9c-b310-f6645ee7ca15</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCRY2PHR-mCherryN1-Linker-BAX(human)</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="1:35:41">2019.3.7</Created>
<LastModified UTC="0:26:14">2025.8.29</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                             	<StrandColors><TopStrand><ColorRange range="1151..1152" colors="red"/><ColorRange range="1178..1195" colors="black"/></TopStrand><BottomStrand><ColorRange range="1151..1152" colors="red"/><ColorRange range="1178..1195" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
